The Science

NutraStem® Science "Based on Science not Science Fiction"

 

NutraStem® - Science According to the U.S. National Institutes of Health, "an adult stem cell is an undifferentiated cell found among differentiated cells in a tissue or organ, can renew itself, and can differentiate to yield the major specialized cell types of the tissue or organ. The primary roles of adult stem cells in a living organism are to maintain and repair the tissue in which they are found."

As we age, the number of adult stem cells within the body begins to decline and lose their ability to function normally, which is very important to maintaining a healthy immune system.

NutraStem® has been specifically formulated from natural compounds that promote the health and normal division (proliferation) of human adult stem cells.

In research that was published in a peer-reviewed journal article we examined the effects of several natural compounds that have been shown to promote healing for their ability to increase the health and normal division of human adult stem cells when grown in culture.

• We exposed three different types of adult stem cells, which are commonly found within the body, to natural compounds that are known to promote healing and measured the growth of these cells (Figure 1).
• Our results demonstrate a significant growth in the cells exposed to blueberry extract, green tea, catechin, carnosine and Vitamin D3, and that a specific combination of these ingredients at certain doses could promote even more growth of these stem cells.
• The control that was used to compare these effects was human granulocyte-macrophage colony-stimulating factor (hGM-CSF) which is used in humans to increase the numbers of stem cells in the blood.

   

	Figure 1 Bickford et al., 2006; Stem Cells and Development HGM-CSF-control BB-blueberry CH-catechin Ca-carosine GT-green tea D3-vitamin D3

 

When the ingredients in NutraStem® are combined together there is a synergistic effect, which means that our proprietary formulation has an effect larger than simply adding together the effects of the individual ingredients (Figure 2) Bickford et al., 2006; Stem Cells and Development.

Figure 2 Bickford et al., 2006; Stem Cells and Development

 

NutraStem® also has been shown to protect bone marrow stem cells from oxidative insult as demonstrated in an in vivo study in the journal of Rejuvenation Research.

Animals were fed NutraStem® in their food for 2 weeks, then the bone marrow was removed and grown in culture, and exposed to H202 (oxidative insult) which resulted in cell death in control animals that did not ingest NutraStem®.

Bone marrow cells from animals that ingested NutraStem® at the high dose showed a decrease in cell death (greater than 50%) and at the low dose (greater than 25%) compared to control animals (Figure 3).

Figure 3 Shytle et al., 2007; Rejuvenation Research Low dose= 13.5mg/kg/day High dose= 135mg/kg/day

 

In addition, NutraStem® has displayed protection against ischemic stroke in an animal model as demonstrated in the journal of Rejuvenation Research (Yasuhara et al., 2008).

Figure 4 Yasuhara et al., 2008; Rejuvenation Research

Moreover, a significant 75% decrease in the stroke glial scar area (scar tissue resulting from stroke) was observed in the ischemic striatum of the NutraStem®-treated stroke animals compared to that of the vehicle-treated stroke animals (Figure 5).

Figure 5 Yasuhara et al., 2008; Rejuvenation Research

Quantitative analysis also revealed that NutraStem® induced neural differentiation, with an increased tendency towards neuronal over glial lineage (Figure 6A & B).

Figure 6 A&B Yasuhara et al., 2008; Rejuvenation Research